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1

Mechanisms of the anti-aging and prolongevity effects of caloric restriction: evidence from studies of genetically modified animals

Hoshino, Shunsuke, Kobayashi, Masaki, Higami, Yoshikazu

Journal:

Year:

2018

Language:

english

File:

PDF, 1.18 MB

english, 2018

2

A Solitary Peutz-Jeghers-Type Hamartomatous Polyp in the Duodenum

Kitaoka, Fumio, Shiogama, Toshiaki, Mizutani, Akimasa, Tsurunaga, Yasutaka, Fukui, Hiroshi, Higami, Yoshikazu, Shimokawa, Isao, Taguchi, Takashi, Kanematsu, Takashi

Journal:

Year:

2004

Language:

english

File:

PDF, 191 KB

english, 2004

3

Introduction

Yoshikazu Higami

Journal:

Microscopy Research and Technique

Year:

2002

Language:

english

File:

PDF, 20 KB

english, 2002

4

Effects of aging and caloric restriction on the gene expression of Foxo1, 3, and 4 (FKHR, FKHRL1, and AFX) in the rat skeletal muscles

Tatsuo Furuyama, Hitoshi Yamashita, Kazuko Kitayama, Yoshikazu Higami, Isao Shimokawa, Nozomu Mori

Journal:

Microscopy Research and Technique

Year:

2002

Language:

english

File:

PDF, 258 KB

english, 2002

5

Impact of aging and life-long calorie restriction on expression of apoptosis-related genes in male F344 rat liver

Kohei Ando, Yoshikazu Higami, Tomoshi Tsuchiya, Takashi Kanematsu, Isao Shimokawa

Journal:

Microscopy Research and Technique

Year:

2002

Language:

english

File:

PDF, 488 KB

english, 2002

6

Anti-aging effects of caloric restriction: Involvement of neuroendocrine adaptation by peripheral signaling

Takuya Chiba, Haruyoshi Yamaza, Yoshikazu Higami, Isao Shimokawa

Journal:

Microscopy Research and Technique

Year:

2002

Language:

english

File:

PDF, 89 KB

english, 2002

7

Lifespan extension by caloric restriction: An aspect of energy metabolism

Haruyoshi Yamaza, Takuya Chiba, Yoshikazu Higami, Isao Shimokawa

Journal:

Microscopy Research and Technique

Year:

2002

Language:

english

File:

PDF, 74 KB

english, 2002

8

The Fas/Fas-ligand system functions in hepatocytes in the early stage of fulminant hepatic failure in rats

Susumu Eguchi, Sumihiro Matsuzaki, Hikaru Fujioka, Takehiko Koji, Yoshikazu Higami, Takashi Kanematsu

Journal:

Hepatology Research

Year:

1998

Language:

english

File:

PDF, 897 KB

english, 1998

9

Clinical experiences of microsurgical side-to-end epididymovasostomy for epididymal obstruction

Jiro Eguchi, Koichiro Nomata, Takeshi Hirose, Naoki Nishimura, Tsukasa Igawa, Hiroshi Kanetake, Yutaka Saito, Yoshikazu Higami

Journal:

International Journal of Urology

Year:

1999

Language:

english

File:

PDF, 61 KB

english, 1999

10

GFAP expression in the subcutaneous tumors of immature glial cell line (HITS glioma) derived from ENU-induced rat glioma

Yuji Ikeno, Isao Shimokawa, Yoshikazu Higami, Takayoshi Ikeda

Journal:

Journal of Neuro-Oncology

Year:

1993

Language:

english

File:

PDF, 3.61 MB

english, 1993

11

Identification of differentially expressed genes in senescence-accelerated mouse testes by suppression subtractive hybridization analysis

Takuya Chiba, Junjie Yao, Yoshikazu Higami, Isao Shimokawa, Masanori Hosokawa, Keiichi Higuchi

Journal:

Mammalian Genome

Year:

2007

Language:

english

File:

PDF, 167 KB

english, 2007

12

Involvement of DNase γ in apoptotic DNA fragmentation in histiocytic necrotizing lymphadenitis

Yoshikazu Higami, Kazuo To, Hiroshi Ohtani, Kenta Masui, Keisuke Iwasaki, Daisuke Shiokawa, Sei-ichi Tanuma, Isao Shimokawa

Journal:

Virchows Archiv

Year:

2003

Language:

english

File:

PDF, 247 KB

english, 2003

13

Primary hepatic lymphoma with spindle cell components: a case report

Hiroko Hayashi, Hiroshi Ohtani, Takashi Ueda, Junzo Yamaguchi, Kunihide Izawa, Takahiro Hayashida, Yoshikazu Higami, Isao Shimokawa

Journal:

Virchows Archiv

Year:

2006

Language:

english

File:

PDF, 487 KB

english, 2006

14

Expression of DNase gamma during Fas-independent apoptotic DNA fragmentation in rodent hepatocytes

Yoshikazu Higami, Tomoshi Tsuchiya, Kazuo To, Takuya Chiba, Haruyoshi Yamaza, Daisuke Shiokawa, Sei-ichi Tanuma, Isao Shimokawa

Journal:

Cell and Tissue Research

Year:

2004

Language:

english

File:

PDF, 224 KB

english, 2004

15

Dietary restriction reduces hepatocyte proliferation and enhances p53 expression but does not increase apoptosis in normal rats during development

Yoshikazu Higami, Isao Shimokawa, Kohei Ando, Kenji Tanaka, Tomoshi Tsuchiya

Journal:

Cell and Tissue Research

Year:

2000

Language:

english

File:

PDF, 454 KB

english, 2000

16

Effect of aging and dietary restriction on hepatocyte proliferation and death in male F344 rats

Yoshikazu Higami, Isao Shimokawa, Tomoaki Okimoto, Masato Tomita, Takane Yuo, Takayoshi Ikeda

Journal:

Cell and Tissue Research

Year:

1997

Language:

english

File:

PDF, 838 KB

english, 1997

17

Apoptosis in the aging process

Yoshikazu Higami, Isao Shimokawa

Journal:

Cell and Tissue Research

Year:

2000

Language:

english

File:

PDF, 81 KB

english, 2000

18

Modulation of oxidative phosphorylation machinery signifies a prime mode of anti-ageing mechanism of calorie restriction in male rat liver mitochondria

Diksha Dani, Isao Shimokawa, Toshimitsu Komatsu, Yoshikazu Higami, Uwe Warnken, Elham Schokraie, Martina Schnölzer, Frank Krause, Michiru D. Sugawa, Norbert A. Dencher

Journal:

Year:

2010

Language:

english

File:

PDF, 364 KB

english, 2010

19

Calorie restriction initiated at a young age activates the Akt/PKCζ/λ-Glut4 pathway in rat white adipose tissue in an insulin-independent manner

Seongjoon Park, Toshimitsu Komatsu, Hiroko Hayashi, Haruyoshi Yamaza, Takuya Chiba, Yoshikazu Higami, Kazunao Kuramoto, Isao Shimokawa

Journal:

Year:

2008

Language:

english

File:

PDF, 266 KB

english, 2008

20

Dietary restriction maintains the basal rate of somatotrope renewal in later life in male rats

Isao Shimokawa, Masato Tomita, Yoshikazu Higami, Tomoaki Okimoto, Toshio Kawahara, Takayoshi Ikeda

Journal:

Year:

1997

Language:

english

File:

PDF, 751 KB

english, 1997

21

In vivo Retrovirus-mediated Herpes Simplex Virus Thymidine Kinase Gene Therapy Approach for Adult T Cell Leukemia in a Rat Model

Ken Murata, Masatoshi Fujita, Yasuaki Yamada, Yoshikazu Higami, Isao Shimokawa, Kunihiro Tsukasaki, Yuetsu Tanaka, Michiyuki Maeda, Koichi Furukawa, Takashi Yoshiki, Hiroshi Shiku, Masao Tomonaga

Journal:

Year:

1997

File:

PDF, 530 KB

1997

22

Fatal Alcaligenes xylosoxidans infection of the liver: Presenting as a liver mass after cholecystectomy

Tomoshi Tsuchiya, Hiroshi Ohtani, Hikaru Fujioka, Akihiko Mizoe, Yoshikazu Higami, Isao Shimokawa

Journal:

Journal of Gastroenterology and Hepatology

Year:

2006

Language:

english

File:

PDF, 167 KB

english, 2006

23

Altered lipid metabolism in rodents subjected to calorie restriction

Yoshikazu Higami, Richard Weindruch, Tomas A Prolla, Isao Shimokawa

Journal:

Geriatrics & Gerontology International

Year:

2004

Language:

english

File:

PDF, 42 KB

english, 2004

24

The Distribution of Tenascin in Rat Embryos with Normal Heart and Cardiovascular Anomalies Induced by Bis-Diamine

Keisuke IWASAKI, Takayoshi IKEDA, Hiroshi OHTANI, Takeshi MATSUO, Yoshikazu HIGAMI, Isao SHIMOKAWA

Journal:

Congenital Anomalies

Year:

1998

Language:

english

File:

PDF, 1.41 MB

english, 1998

25

Impact of Growth Hormone Suppression in the Aging Process and Preliminary Longevity Analysis

Isao Shimokawa, Yoshikazu Higami, Kurumi Yanagihara-Outa, Kenji Tanaka, Tomoshi Tuchiya, Takahito Kondo, Shinji Goto

Journal:

Annals of the New York Academy of Sciences

Year:

2001

Language:

english

File:

PDF, 78 KB

english, 2001

26

Identification of Fasting-induced Genes in the Rat Hypothalamus : Relationship with Neuroprotection

TAKUYA CHIBA, SATOSHI FUJITA, HARUAKI KUBOTA, DAISUKE INOUE, AYA MIZUNO, TOSHIMITSU KOMATSU, HARUYOSHI YAMAZA, YOSHIKAZU HIGAMI, ISAO SHIMOKAWA

Journal:

Annals of the New York Academy of Sciences

Year:

2007

Language:

english

File:

PDF, 106 KB

english, 2007

27

Pleomorphic adenoma of the breast: Report of a case

Nobuo Mochinaga, Takashi Yatsugi, Shigeo Tomokawa, Tamotsu Ishida, Hiroshi Ohtani, Yoshikazu Higami

Journal:

Year:

1997

Language:

english

File:

PDF, 1.38 MB

english, 1997

28

Malignant mesothelioma of the tunica vaginalis testis: Report of a case

Shigeo Kanazawa, Taka-aki Nagae, Takashi Fujiwara, Rie Fujiki, Norishige Mukai, Yoshiaki Sugihara, Noboru Yamaguchi, Hiroshi Ohtani, Yoshikazu Higami, Takayoshi Ikeda, Tsukasa Tsunoda

Journal:

Year:

1999

Language:

english

File:

PDF, 424 KB

english, 1999

29

Susceptibility of hepatocytes to cell death induced by single administration of cycloheximide in young and old F344 rats effect of dietary restriction

Yoshikazu Higami, Isao Shimokawa, Tomoaki Okimoto, Masato Tomita, Takane Yuo, Takayoshi Ikeda

Journal:

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Year:

1996

Language:

english

File:

PDF, 627 KB

english, 1996

30

Aging increases DNase γ, an apoptosis-related endonuclease, in rat liver nuclei: effect of dietary restriction

Kenji Tanaka, Yoshikazu Higami, Tomoshi Tsuchiya, Daisuke Shiokawa, Sei-ichi Tanuma, Hiroyoshi Ayabe, Isao Shimokawa

Journal:

Experimental Gerontology

Year:

2004

Language:

english

File:

PDF, 277 KB

english, 2004

31

A transgenic dwarf rat model as a tool for the study of calorie restriction and aging

Haruyoshi Yamaza, Toshimitsu Komatsu, Takuya Chiba, Hiroaki Toyama, Kazuo To, Yoshikazu Higami, Isao Shimokawa

Journal:

Experimental Gerontology

Year:

2004

Language:

english

File:

PDF, 105 KB

english, 2004

32

Calorie restriction initiated at middle age improved glucose tolerance without affecting age-related impairments of insulin signaling in rat skeletal muscle

Seongjoon Park, Toshimitsu Komatsu, Hiroko Hayashi, Haruyoshi Yamaza, Takuya Chiba, Yoshikazu Higami, Kazunao Kuramoto, Isao Shimokawa

Journal:

Experimental Gerontology

Year:

2006

Language:

english

File:

PDF, 458 KB

english, 2006

33

Manipulation of caloric content but not diet composition, attenuates the deficit in learning and memory of senescence-accelerated mouse strain P8

Toshimitsu Komatsu, Takuya Chiba, Haruyoshi Yamaza, Kimihiro Yamashita, Atsuyoshi Shimada, Yasuyo Hoshiyama, Tomoko Henmi, Hiroshi Ohtani, Yoshikazu Higami, Rafael de Cabo, Donald K. Ingram, Isao Shim

Journal:

Experimental Gerontology

Year:

2008

Language:

english

File:

PDF, 491 KB

english, 2008

34

Calorie restriction minimizes activation of insulin signaling in response to glucose: Potential involvement of the growth hormone-insulin-like growth factor 1 axis

Hiroko Hayashi, Haruyoshi Yamaza, Toshimitsu Komatsu, Seongjoon Park, Takuya Chiba, Yoshikazu Higami, Takeshi Nagayasu, Isao Shimokawa

Journal:

Experimental Gerontology

Year:

2008

Language:

english

File:

PDF, 397 KB

english, 2008

35

Pituitary growth hormone suppression reduces resistin expression and enhances insulin effectiveness: Relationship with caloric restriction

Takuya Chiba, Haruyoshi Yamaza, Toshimitsu Komatsu, Masahiko Nakayama, Satoshi Fujita, Hiroko Hayashi, Yoshikazu Higami, Isao Shimokawa

Journal:

Experimental Gerontology

Year:

2008

Language:

english

File:

PDF, 204 KB

english, 2008

36

Acute stress response in calorie-restricted rats to lipopolysaccharide-induced inflammation

Tomoshi Tsuchiya, Yoshikazu Higami, Toshimitsu Komatsu, Kenji Tanaka, Sumihisa Honda, Haruyoshi Yamaza, Takuya Chiba, Hiroyoshi Ayabe, Isao Shimokawa

Journal:

Mechanisms of Ageing and Development

Year:

2005

Language:

english

File:

PDF, 320 KB

english, 2005

37

Differential responses of white adipose tissue and brown adipose tissue to caloric restriction in rats

Naoyuki Okita, Yusuke Hayashida, Yumiko Kojima, Mayumi Fukushima, Keiko Yuguchi, Kentaro Mikami, Akiko Yamauchi, Kyoko Watanabe, Mituru Noguchi, Megumi Nakamura, Toshifusa Toda, Yoshikazu Higami

Journal:

Mechanisms of Ageing and Development

Year:

2012

Language:

english

File:

PDF, 1.74 MB

english, 2012

38

Intravenous injection of cycloheximide induces apoptosis and up-regulates p53 and Fas receptor expression in the rat liver in vivo

Yoshikazu Higami, Kenji Tanaka, Tomoshi Tsuchiya, Isao Shimokawa

Journal:

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Year:

2000

Language:

english

File:

PDF, 143 KB

english, 2000

39

Leptin signaling and aging: insight from caloric restriction

Isao Shimokawa, Yoshikazu Higami

Journal:

Mechanisms of Ageing and Development

Year:

2001

Language:

english

File:

PDF, 109 KB

english, 2001

40

EPO-producing gastric carcinoma in a hemodialysis patient

Manabu Matsuo, Shigehiko Koga, Hiroshi Kanetake, Hiroshi Ohtani, Yoshikazu Higami, Isao Shimokawa, Jun-ichi Watanabe

Journal:

American Journal of Kidney Diseases

Year:

2003

Language:

english

File:

PDF, 123 KB

english, 2003

41

Primary low-grade MALT lymphoma of the gallbladder

Tomoshi Tsuchiya, Isao Shimokawa, Yoshikazu Higami, Hiroshi Ohtani, Yuji Shigeoka, Koichi Ohshima, Kenji Tanaka, Hiroyoshi Ayabe

Journal:

Pathology International

Year:

2001

Language:

english

File:

PDF, 145 KB

english, 2001

42

Minigemistocytic astrocytoma with frequent apoptoses: Analysis of tumor growth

Yoshikazu Higami, Isao Shlmokawa, Tomoaki Okimoto, Hiroshi Otani, Masao Kishikawa, Takafumi Zlnnouchi, Tsuyoshi Hiura, Syuhei Nishimura, Takayoshi Ikeda

Journal:

Pathology International

Year:

1995

Language:

english

File:

PDF, 2.34 MB

english, 1995

43

Spontaneous rupture of non-aneurysmal ascending aorta

Masato Tomita, Isao Shimokawa, Takayoshi Ikeda, Keisuke Iwasaki, Yoshikazu Higami, Hiroshi Ohtani, Tetsuro Matsushita, Jun Fukui, Masahiro Shikuwa

Journal:

Pathology International

Year:

1996

Language:

english

File:

PDF, 1.90 MB

english, 1996

44

An Mdm2 antagonist, Nutlin-3a, induces p53-dependent and proteasome-mediated poly(ADP-ribose) polymerase1 degradation in mouse fibroblasts

Shingo Matsushima, Naoyuki Okita, Misako Oku, Wataru Nagai, Masaki Kobayashi, Yoshikazu Higami

Journal:

Biochemical and Biophysical Research Communications

Year:

2011

Language:

english

File:

PDF, 411 KB

english, 2011

45

Reversible induction of PARP1 degradation by p53-inducible cis-imidazoline compounds

Wataru Nagai, Naoyuki Okita, Hiroshi Matsumoto, Hitoshi Okado, Misako Oku, Yoshikazu Higami

Journal:

Biochemical and Biophysical Research Communications

Year:

2012

Language:

english

File:

PDF, 531 KB

english, 2012

46

Similar metabolic responses to calorie restriction in lean and obese Zucker rats

Takuya Chiba, Toshimitsu Komatsu, Masahiko Nakayama, Toshiyuki Adachi, Yukari Tamashiro, Hiroko Hayashi, Haruyoshi Yamaza, Yoshikazu Higami, Isao Shimokawa

Journal:

Molecular and Cellular Endocrinology

Year:

2009

Language:

english

File:

PDF, 783 KB

english, 2009

47

Life Span Extension by Reduction in Growth Hormone-Insulin-Like Growth Factor-1 Axis in a Transgenic Rat Model

Isao Shimokawa, Yoshikazu Higami, Masanori Utsuyama, Tomoshi Tuchiya, Toshimitsu Komatsu, Takuya Chiba, Haruyoshi Yamaza

Journal:

The American Journal of Pathology

Year:

2002

Language:

english

File:

PDF, 213 KB

english, 2002

48

Effects of caloric restriction on gene expression in the arcuate nucleus

Isao Shimokawa, Tamaki Fukuyama, Kurumi Yanagihara-Outa, Masato Tomita, Toshimitsu Komatsu, Yoshikazu Higami, Tomoshi Tuchiya, Takuya Chiba, Yoshiharu Yamaza

Journal:

Neurobiology of Aging

Year:

2003

Language:

english

File:

PDF, 182 KB

english, 2003

49

BRAF and K-ras gene mutations in human pancreatic cancers

Norihisa Ishimura, Kunihiro Yamasawa, Mohammad Azharul Karim Rumi, Yasunori Kadowaki, Shunji Ishihara, Yuji Amano, Yoshinori Nio, Tetsuya Higami, Yoshikazu Kinoshita

Journal:

Year:

2003

Language:

english

File:

PDF, 124 KB

english, 2003

50

CHK1 cleavage in programmed cell death is intricately regulated by both caspase and non-caspase family proteases

Naoyuki Okita, Miyuki Yoshimura, Kazuhito Watanabe, Shota Minato, Yuki Kudo, Yoshikazu Higami, Sei-ichi Tanuma

Journal:

Biochimica et Biophysica Acta (BBA) - General Subjects

Year:

2013

File:

PDF, 516 KB

2013

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